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Knockdown of miR-21 Expression Sensitizes Cancer Cell to Apoptosis Induced by Interferon
The micro RNA, miR-21, is overexpressed in many human cancers, and accumulating evidence indicates that miR-21 has oncogenic activity. Here we report that the cytokine IFNa/b rapidly induced the miR-21 transcript in several human and mouse cell lines. Pathways known to be involved in regulating cell death were identified as downstream targets for miR-21,... (read more)