Use of Recombinant VSV to Study Virus Entry, Glycoprotein Assembly, Immune Responses to Vaccines, and to Identify Cellular Receptors and Virus Entry Inhibitors
Published:7/14/2015Description:
A system to recover recombinant viruses from plasmids, and viruses that lack the VSV envelope glycoprotein (delta-G VSV) that also contain reporter genes (GFP, Ds-Red and Luciferase) has been developed. This technology is used to study the entry of heterologous viruses via incorporation of other viral G proteins into replicating (recovered from plasmids) or non-replicating (delta-G) viruses. The system can also be used to study immune responses to vaccines and to identiy cell receptors and entry inhibitors.